Crohn’s disease (CD) affects the entire gastrointestinal tract. The incidence of IBD is increasing in western and developing countries. Inflammatory bowel disease (IBD) is a global health issue. plantarum in the human gut environment and its’ potential for remission of IBD. This overview of the molecular studies addresses the activity of L. The blocking of cyclooxygenase-2 in Th1 also is an apoptotic inhibition mechanism. plantarum modulates the ratio of Th1 and Th2 cells by stimulating the production of different inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, IL-10, IL-12, and interferon-gamma. plantarum in vitro and in animal models for the prevention and management of IBD. This review summarizes the safety and the effects of L. plantarum consumption on human physiology. Several studies have described the effects of L. Lactobacillus plantarum is distributed in a variety of ecological niches, has a proven ability to survive gastric transit, and can colonize the intestinal tract of human and other mammals. Altered gut bacteria and bacterial metabolic pathways are two important factors in the initiation and progression of IBD. The incidence of inflammatory bowel disease (IBD) is increasing globally.
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